Non-Invasive Prenatal Testing

About the Panorama Test

Panorama is a non-invasive DNA screening test that can tell you important information about your pregnancy, from as early as nine weeks of gestation. You can find out the likelihood of your baby having a condition such as Down syndrome and all that’s required is a sample of your blood. If you choose, you can also find out the gender of your baby.

Is Panorama right for me?

According to the International Society for Prenatal Diagnosis (ISPD), non-invasive prenatal testing (like the Panorama Test) is appropriate as a primary screening test for pregnant women of all ages. Down Syndrome and certain other chromosomal conditions occur more frequently in babies born to mothers over 35 years old. Other conditions for which Panorama screens – such as microdeletion syndromes – occur with the same frequency in babies, regardless of the mother’s age.

Currently, Panorama cannot be used in the following types of pregnancies:

  • Multiple gestation pregnancies with 3 or more fetuses
  • Pregnant women who are bone marrow transplant recipients

What Panorama Screens For

Panorama is the only non-invasive prenatal screening test that distinguishes between fetal and maternal cell-free DNA thanks to SNP-based sequencing and Natera’s proprietary algorithm. Using advanced bioinformatics techniques, Panorama screens for a broad panel of chromosomal conditions, including:

Chromosome Conditions

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Triploidy

Sex Chromosome Conditions

  • Monosomy X (Turner syndrome)
  • Klinefelter syndrome
  • Triple X syndrome
  • XYY syndrome


  • 2 deletion syndrome
  • 1p36 deletion syndrome
  • Prader Willi syndrome
  • Angelman syndrome
  • Cri-du-chat syndrome
  • Gender of the Baby (optional)

In Twin Pregnancies

Non-identical or fraternal twins

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Gender of each twin (optional)

If our screening finds that your twins are identical, Panorama can additionally screen for:

  • Monosomy X (Turner syndrome)
  • Sex chromosome trisomies
  • 2 deletion syndrome (optional)

Egg Donor or Surrogate Pregnancies

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Gender (optional)

How accurate is the test?

Clinical studies have shown exceptional accuracy for detecting fetal trisomy.

What does the DETECTION RATE mean?

The detection rate or sensitivity is the ability to correctly identify a baby with a specific condition. For example, in a group of babies with Trisomy 21, Panorama will correctly identify more than 99% of those cases.


This is the ability to correctly identify an unaffected baby.


This is the likelihood that if the result says high probability then the fetus will actually have the condition. For example, when the Panorama Test shows a high probability of Trisomy 21, then there is a 91% chance that the fetus will actually have Trisomy 21.  For Trisomy 13, the PPV is however only 38% (see the information in the ‘learn more’ section).


This is the likelihood that the result says low probability, the fetus will not have the condition.

What do the results means?

What does a HIGH PROBABILITY result mean?

A HIGH PROBABILITY result is indicative of a high likelihood for a condition. The actual likelihood of a fetus with the condition depends on the condition being screened for and is the PPV (see the table in the ‘learn more’ section for detailed information on each condition). After the test, the number of women required to consider a CVS or an amniocentesis is less than 1%. It is important to note that if the test results show there is a HIGH  PROBABILITY that the fetus has trisomy 21, 18 or 13, it does not mean that the fetus definitely has one of these conditions, although it is highly likely. For this reason, in the event of a high probability (or positive) result, follow-up testing by an invasive procedure is recommended.

What does a LOW PROBABILITY result mean?

If the test results show that there is a LOW PROBABILITY that the fetus has a condition, it is unlikely that the fetus has it. The actual likelihood depends on the condition being screened for and is the NPV (see the table in the ‘learn more’ section for detailed information on each condition). It is important to know that not all trisomy fetuses will be detected. All results should be interpreted by a clinician in the context of clinical and familial data: patients should continue with their usual scan appointments and care following testing.

How long will it take to get results?

Results are usually reported within 2 weeks. In about 3% of tests, a result is not possible (usually because there is not enough fetal DNA in the original blood sample). When this happens, a repeat blood test may be required and this is done at no extra cost.

Are there any risks to the pregnancy from the Panorama Test?

No. The testing is non-invasive: it involves taking a blood sample from the mother. The pregnancy is not put at risk of miscarriage or from other adverse outcomes that are associated with invasive testing procedures such as CVS or amniocentesis.